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- Aprendiz de Músico
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In silico introduction of the double mutation D1-A209S/D1- C212S to the resolved structure of T. elongatus provides insight into the structural and energetic differences between PSIIRC of wild-type Synechocystis sp. PCC 6803 and the AC mutant. Hereafter, we will refer to the structure of PSIIRC from T. elongatus as TWS119 GSK-3 inhibitorrepresenting the putative structure of the AC, and the one obtained by in silico D1-A209S/D1-C212S double mutation, as representing the structure of DKS. PCC 6803. The molecular dynamics simulations have provided insight into the interaction potential of the D helices of the D1 and D2 proteins. An additional hydrogen bond was observed between D1-Ser209Oc and D2-Ile204O. As a result of this change in the inter-helical hydrogen bond network, the D helices of the modeled mesophilic D1 and D2 proteins take on U0126 MEK inhibitor a conformation that is different from the thermophilic one. Thus, to form the new H-bond there is a need for a more relaxed environment. It is well known that the photosynthetic membrane lipids present increased saturation with increasing temperature in different strains of cyanobacteria and higher organisms.
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